Cayenne

A red pepper used as both spice and medicine. The heat comes from capsaicin, the same compound that triggers a burning sensation — and capsaicin cream has some of the strongest pain-relief evidence in...

• Topical Capsaicin Cream Eases Nerve Pain — Diabetic Neuropathy, Lingering Pain After Shingles, Hiv-Related Nerve Pain
• Topical Capsaicin Eases Osteoarthritis Pain — One Of Its Best-Studied Uses
• Works By Depleting Substance P, The Chemical Messenger Nerves Use To Send Pain Signals — Relief Builds Over Days Of Consistent Use
• Long Traditional Use As A Digestive Stimulant

Note Initial application causes burning that fades with consistent use — this is expected, not a sign to stop Note Wash hands thoroughly after handling — capsaicin transfers to eyes and mucous membranes easily and painfully