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THYROID FUNCTION

Chromium

Cr — Element #24

also known as Chromium picolinate, Chromium chloride, Chromium nicotinate, Trivalent chromium

Chromium (as trivalent Cr³⁺) has been proposed to potentiate insulin signaling, possibly through a chromium-binding oligopeptide called chromodulin. However, whether chromium is truly essential for humans remains scientifically debated, and the evidence for chromium supplementation improving glucose metabolism in healthy or diabetic individuals is mixed and generally weak. No Recommended Dietary Allowance (RDA) has been established; only an Adequate Intake (AI).

  • May enhance insulin receptor sensitivity, potentially supporting blood glucose regulation — evidence is inconsistent
  • Chromodulin (low-molecular-weight chromium-binding substance) may amplify insulin signal transduction
  • Chromium picolinate supplements are widely used for blood sugar control and weight management, though clinical trial evidence is not conclusive
  • May play a role in macronutrient metabolism (carbohydrate, lipid, and protein)

Active in Cr³⁺ (trivalent chromium), Chromodulin.

No established UL; the Adequate Intake (AI) is 25–35 mcg/day for adults (not an RDA)
Hexavalent chromium (Cr⁶⁺), found in industrial settings, is a known carcinogen — do not confuse with dietary trivalent chromium (Cr³⁺)
High-dose chromium picolinate supplements have been associated with kidney toxicity in isolated case reports
Individuals with kidney or liver disease should use chromium supplements with caution
The scientific consensus does not support chromium supplementation as an evidence-based treatment for type 2 diabetes

NIH ODS — Chromium · MedlinePlus — Chromium in diet · Britannica — Chromium

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The curious few.
50 founding spots left

Know what you're putting in your body.

158 herbs, nutrients, and compounds. What the science says, what tradition knew, and what to watch for. Founding members keep this running.

$60 /year

Founding rate — locked for life. Regular price after launch: $96/year.

  • ✓ Full access to all 158+ entries
  • ✓ Print-ready reference card for every herb
  • ✓ Monthly curated set — 5 herbs, one body system
  • ✓ The Sunday Letter — weekly research digest
  • ✓ Bookmarks synced across devices
  • ✓ Founding rate locked forever
Become a founding member

Cancel any time. No questions asked.