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GENERAL IMMUNITY

Cat's Claw

Uncaria tomentosa

also known as uña de gato

Moderate

A South American rainforest vine named for the cat-claw-shaped thorns along its stems. Used by Indigenous Amazonian peoples (the Asháninka in particular) for centuries for inflammation, infections, and a wide range of conditions. Modern research focuses on inflammation and immune support, with the most consistent evidence for joint conditions.

  • May ease joint pain and stiffness in osteoarthritis and rheumatoid arthritis
  • Anti-inflammatory action documented in modern research
  • Long traditional Amazonian use as a general healing vine — for inflammation, infections, digestive complaints
  • Immune-modulating activity in laboratory studies
  • Two chemotypes exist — the pentacyclic oxindole alkaloid (POA) chemotype is the one used medicinally; the tetracyclic chemotype has different and potentially undesirable effects
  • Best research uses standardized extracts of the POA chemotype (TOA-free)
Skip with autoimmune conditions — cat's claw modulates immune signaling, with effects that can run either direction
Use caution with immunosuppressants — including post-transplant medications
Mild blood-thinning effect — caution with blood thinners
May lower blood pressure — caution with blood pressure medications
Skip during pregnancy — traditional use as a contraceptive
Skip during nursing
Use caution with hormonal medications
Stop two weeks before surgery
Make sure product is the U. tomentosa species — U. guianensis is also sold as cat's claw and has different properties

NCCIH — Cat's Claw · MedlinePlus Herbs & Supplements · NIH NCCIH Herbs at a Glance

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The curious few.
50 founding spots left

Know what you're putting in your body.

158 herbs, nutrients, and compounds. What the science says, what tradition knew, and what to watch for. Founding members keep this running.

$60 /year

Founding rate — locked for life. Regular price after launch: $96/year.

  • ✓ Full access to all 158+ entries
  • ✓ Print-ready reference card for every herb
  • ✓ Monthly curated set — 5 herbs, one body system
  • ✓ The Sunday Letter — weekly research digest
  • ✓ Bookmarks synced across devices
  • ✓ Founding rate locked forever
Become a founding member

Cancel any time. No questions asked.