Cat's Claw
Uncaria tomentosa
also known as uña de gato
Moderate
A South American rainforest vine named for the cat-claw-shaped thorns along its stems. Used by Indigenous Amazonian peoples (the Asháninka in particular) for centuries for inflammation, infections, and a wide range of conditions. Modern research focuses on inflammation and immune support, with the most consistent evidence for joint conditions.
- May ease joint pain and stiffness in osteoarthritis and rheumatoid arthritis
- Anti-inflammatory action documented in modern research
- Long traditional Amazonian use as a general healing vine — for inflammation, infections, digestive complaints
- Immune-modulating activity in laboratory studies
- Two chemotypes exist — the pentacyclic oxindole alkaloid (POA) chemotype is the one used medicinally; the tetracyclic chemotype has different and potentially undesirable effects
- Best research uses standardized extracts of the POA chemotype (TOA-free)
Skip with autoimmune conditions — cat's claw modulates immune signaling, with effects that can run either direction
Use caution with immunosuppressants — including post-transplant medications
Mild blood-thinning effect — caution with blood thinners
May lower blood pressure — caution with blood pressure medications
Skip during pregnancy — traditional use as a contraceptive
Skip during nursing
Use caution with hormonal medications
Stop two weeks before surgery
Make sure product is the U. tomentosa species — U. guianensis is also sold as cat's claw and has different properties
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