Inositol
also known as Inositol
Moderate (PCOS, anxiety)
A sugar-alcohol the body makes from glucose, sometimes called vitamin B8 in older texts. Once thought to be essential like a vitamin, it's now classified as a vitamin-like compound — but supplementation has real evidence for polycystic ovary syndrome, anxiety, and metabolic balance.
- Strong evidence for polycystic ovary syndrome — improves ovulation, insulin sensitivity, and androgen balance
- Best PCOS results come from a 40:1 ratio of myo-inositol to D-chiro-inositol, mirroring the body's natural ratio
- May ease anxiety and panic disorder at higher doses (typically 12-18 grams daily)
- May support fertility, particularly egg quality in women with PCOS
- Supports healthy blood sugar and insulin sensitivity
- Found naturally in fruits, beans, grains, and nuts — supplementation is well tolerated
Generally well tolerated, but high doses can cause loose stools, nausea, and headache
Use caution with bipolar disorder — may trigger mood elevation in sensitive people
May interact with lithium
May lower blood sugar — caution with diabetes medication
Pregnancy use should be guided by a provider, though it's commonly used for gestational diabetes prevention in PCOS
Effects on PCOS build over 3 to 6 months — not a quick fix
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