PABA
also known as PABA, Para-Aminobenzoic Acid
Weak (most claims) / specific (Peyronie's, scleroderma)
A small molecule once classified as a B vitamin before researchers determined that humans don't actually need it — bacteria in the gut produce it, and it serves as a building block for folate. Most consumer claims for PABA have not held up, but it has a niche prescription role for two specific connective tissue conditions.
- Used as a prescription medication (Potaba) for Peyronie's disease and scleroderma — the only well-supported uses
- Historically marketed for hair color, vitiligo, and skin conditions, though evidence is weak
- Was a common sunscreen ingredient before being largely replaced due to allergic reactions and skin staining
- Made by gut bacteria — humans do not have a dietary requirement
Reduces the effectiveness of sulfa antibiotics (sulfonamides) — never combine
Can cause liver injury at higher doses, including some serious cases
Can cause low blood sugar and reduced white blood cell counts at high doses
Common allergen — can cause skin rash and contact dermatitis
Skip with kidney or liver disease
Skip during pregnancy and nursing
Generally not needed as a supplement — most consumer claims lack solid support
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