Know what you're putting in your body.

158 herbs, nutrients, and compounds. What the science says, what tradition knew, and what to watch for. Founding members keep this running.

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MOOD

St. John's wort

Hypericum perforatum

also known as Hypericum, Tipton's weed, Klamath weed

A yellow-flowered herb with strong evidence for mild to moderate depression, but a long list of serious drug interactions makes it the most caution-requiring herb in common use.

Strong evidence for mild to moderate depression
Comparable to standard antidepressants in some trials
Modulates serotonin, dopamine, and norepinephrine
Provides antioxidant flavonoids
Approved in Germany for mild depression
Used since ancient Greek medicine

Active in Hypericin, Hyperforin, Flavonoids, Tannins.

Major drug interaction warning — induces CYP3A4 enzyme

Reduces effectiveness of birth control pills

Reduces effectiveness of HIV medications, organ transplant drugs, blood thinners, and many others

Risk of serotonin syndrome with SSRIs/SNRIs

Causes photosensitivity — avoid sun exposure

Avoid in pregnancy and nursing

Discontinue 2 weeks before surgery

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