Know what you're putting in your body.

158 herbs, nutrients, and compounds. What the science says, what tradition knew, and what to watch for. Founding members keep this running.

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GENERAL IMMUNITY

Thunder God Vine

Tripterygium wilfordii

also known as lei gong teng

A climbing vine native to China, called lei gong teng in traditional Chinese medicine, used for centuries for autoimmune and inflammatory conditions. Modern research backs the rheumatoid arthritis benefit — but thunder god vine is one of the most toxic medicinal plants still in regular use. The same compounds that suppress an overactive immune system can also suppress fertility, damage organs, and cause death. This is a herb for trained practitioners with bloodwork monitoring, not the supplement aisle.

Real evidence for easing rheumatoid arthritis symptoms — pain, swelling, joint stiffness
Some evidence for other autoimmune conditions, including lupus and ankylosing spondylitis
Suppresses the immune signals that drive autoimmune inflammation — comparable in some studies to standard rheumatoid arthritis medications
Long traditional Chinese medicine use specifically for inflammatory and autoimmune conditions
Best-studied form is a refined extract of the root xylem; whole-plant preparations carry higher toxicity

Has caused death — at toxic doses, thunder god vine causes multi-organ failure including kidney and heart damage

Causes infertility in men and menstrual disruption in women, sometimes irreversibly

Suppresses bone marrow function — can cause low blood counts, severe immune suppression, and serious infection

Causes liver injury at therapeutic doses in some people

Should only be used under supervision by a practitioner trained in Chinese medicine, with regular bloodwork, kidney function, and liver function monitoring

Skip during pregnancy — causes miscarriage and birth defects

Skip during nursing

Skip with any plan for future fertility

Skip with osteoporosis — thunder god vine accelerates bone loss

Skip with low blood counts, kidney disease, or liver disease

Multiple national agencies have flagged thunder god vine for restricted use; quality control varies enormously

Self-experimentation with this herb has caused serious harm and death — this is not appropriate for casual self-treatment

NCCIH — Thunder God Vine · MedlinePlus Herbs & Supplements · NIH NCCIH Herbs at a Glance

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