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Know what you're putting in your body.

158 herbs, nutrients, and compounds. What the science says, what tradition knew, and what to watch for. Founding members keep this running.

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GUT HEALTH

Barberry

Berberis vulgaris

also known as berberis, barberry root

Moderate

A spiny European shrub whose root, bark, and red berries have been used in medicine since ancient Egyptian times. Like goldenseal and Oregon grape, barberry contains alkaloid found in barberry, goldenseal, and Oregon grape. Has real antimicrobial action and affects how the liver processes many medications. Increasingly studied for blood sugar and cholesterol effects.">berberine — the bright yellow alkaloid behind most of its activity. More sustainable than goldenseal and traditionally used for digestive, liver, and metabolic complaints across European, Persian, and Indian medicine.

  • Bitter digestive support — stimulates bile flow and digestive secretions
  • alkaloid found in barberry, goldenseal, and Oregon grape. Has real antimicrobial action and affects how the liver processes many medications. Increasingly studied for blood sugar and cholesterol effects.">Berberine is increasingly studied for healthy blood sugar and cholesterol balance, with growing modern research
  • Antimicrobial action from alkaloid found in barberry, goldenseal, and Oregon grape. Has real antimicrobial action and affects how the liver processes many medications. Increasingly studied for blood sugar and cholesterol effects.">berberine — active against bacteria, fungi, and parasites in laboratory studies
  • Traditional use for liver and gallbladder support
  • The red berries are tart and rich in vitamin C — used as a culinary spice in Persian cuisine
  • More sustainable alkaloid found in barberry, goldenseal, and Oregon grape. Has real antimicrobial action and affects how the liver processes many medications. Increasingly studied for blood sugar and cholesterol effects.">berberine source than the over-harvested goldenseal
Skip during pregnancy — berberine can cross the placenta and may cause newborn jaundice
Skip during nursing — berberine can transfer to infants and cause kernicterus
Skip in infants and small children
Berberine interacts with many medications by affecting how the liver metabolizes them — caution with prescription drugs in general
Use caution with diabetes medication — may lower blood sugar further
Use caution with blood pressure medications
Use caution with antibiotics — berberine has its own antimicrobial activity
Limit continuous use to a few weeks
The curious few.
50 founding spots left

Know what you're putting in your body.

158 herbs, nutrients, and compounds. What the science says, what tradition knew, and what to watch for. Founding members keep this running.

$60 /year

Founding rate — locked for life. Regular price after launch: $96/year.

  • Full access to all 158+ entries
  • Print-ready reference card for every herb
  • Monthly curated set — 5 herbs, one body system
  • The Sunday Letter — weekly research digest
  • Bookmarks synced across devices
  • Founding rate locked forever
Become a founding member

Cancel any time. No questions asked.