A South American rainforest vine named for the cat-claw-shaped thorns along its stems. Used by Indigenous Amazonian peoples (the Asháninka in particular) for centuries for inflammation, infections, and a wide range of conditions. Modern research focuses on inflammation and immune support, with the most consistent evidence for joint conditions.

May ease joint pain and stiffness in osteoarthritis and rheumatoid arthritis
Anti-inflammatory action documented in modern research
Long traditional Amazonian use as a general healing vine — for inflammation, infections, digestive complaints
Immune-modulating activity in laboratory studies
Two chemotypes exist — the pentacyclic oxindole alkaloid (POA) chemotype is the one used medicinally; the tetracyclic chemotype has different and potentially undesirable effects
Best research uses standardized extracts of the POA chemotype (TOA-free)

Skip with autoimmune conditions — cat's claw modulates immune signaling, with effects that can run either direction

Use caution with immunosuppressants — including post-transplant medications

Mild blood-thinning effect — caution with blood thinners

May lower blood pressure — caution with blood pressure medications

Skip during pregnancy — traditional use as a contraceptive

Skip during nursing

Use caution with hormonal medications

Stop two weeks before surgery

Make sure product is the U. tomentosa species — U. guianensis is also sold as cat's claw and has different properties

NCCIH — Cat's Claw · MedlinePlus Herbs & Supplements · NIH NCCIH Herbs at a Glance

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