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MIGRAINE

Feverfew

Tanacetum parthenium

also known as Featherfew, Bachelor's button

Moderate (migraine prevention)

A daisy-family herb with traditional use and modest evidence for reducing migraine frequency through serotonin and prostaglandin modulation.

  • May reduce migraine frequency
  • Modulates serotonin and inhibits prostaglandins
  • Approved in Canada for migraine prevention
  • Used since the first century
  • Most effective at standardized parthenolide content

Active in Parthenolide, Sesquiterpene lactones, Flavonoids.

Possible cross-reactivity with Asteraceae allergy
Mouth ulcers possible from chewing fresh leaves
Avoid in pregnancy — uterine stimulant
Use caution with blood thinners
Discontinuation may cause rebound headache
Discontinue 2 weeks before surgery

NIH NCCIH Herbs at a Glance · MedlinePlus Herbs & Supplements

Works with
Ginger Feverfew (parthenolide, serotonin inhibition) and ginger (5-HT3 antagonism, prostaglandin inhibition) have complementary mechanisms for migraine and nausea.
Use with caution
Ginkgo Feverfew (antiplatelet, serotonin inhibition) and ginkgo (PAF inhibition) have additive antiplatelet effects; avoid combining with anticoagulant drugs.
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