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HEART FUNCTION

Grape Seed Extract

Vitis vinifera

also known as grape seed

Moderate
Grape Seed Extract — Köhler 1887 botanical illustration

A concentrated extract from the seeds left over after winemaking, rich in a family of antioxidants called proanthocyanidins. Best evidence is for blood vessel support and circulation — particularly leg circulation and the visible signs of poor venous return.

  • Eases symptoms of chronic venous insufficiency — heavy legs, swelling, visible veins
  • Strengthens capillary walls and reduces fragility
  • Powerful antioxidant action against multiple types of free radicals
  • May modestly lower blood pressure
  • May help reduce post-exercise muscle soreness
  • Often combined with vitamin C, which it appears to recycle and extend
Use caution with blood thinners — grape seed extract has mild anticoagulant action
May lower blood pressure — caution combining with blood pressure medication
Stop two weeks before surgery
Skip during pregnancy and nursing — limited safety data
Generally well tolerated but may cause mild stomach upset or headache in some people
Research

NCCIH — Grape Seed Extract · MedlinePlus Herbs & Supplements · NIH NCCIH Herbs at a Glance

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The curious few.
50 founding spots left

Know what you're putting in your body.

158 herbs, nutrients, and compounds. What the science says, what tradition knew, and what to watch for. Founding members keep this running.

$60 /year

Founding rate — locked for life. Regular price after launch: $96/year.

  • ✓ Full access to all 158+ entries
  • ✓ Print-ready reference card for every herb
  • ✓ Monthly curated set — 5 herbs, one body system
  • ✓ The Sunday Letter — weekly research digest
  • ✓ Bookmarks synced across devices
  • ✓ Founding rate locked forever
Become a founding member

Cancel any time. No questions asked.