Wild Yam
also known as colic root
A North American climbing vine whose root has a long traditional use for menstrual cramps, digestive complaints, and joint pain. Wild yam contains diosgenin, a plant compound that pharmaceutical chemists used in the 1940s as a starting point to synthesize progesterone, cortisone, and birth control hormones in the lab. But the body cannot do this same conversion — wild yam itself does not produce hormones in the body, despite extensive marketing claims to the contrary.
- Traditional use for menstrual cramps and painful periods — the antispasmodic effect is the genuine traditional use
- Long traditional use for digestive cramping and irritable bowel-type complaints
- Mild anti-inflammatory action useful for joint and muscle discomfort
- Diosgenin (the plant steroid) was the laboratory starting point for synthetic progesterone, cortisone, and the first birth control pills — a real piece of pharmaceutical history
- Topical wild yam creams have been marketed for menopause and PMS, though the human body cannot convert diosgenin to progesterone — any effect from these creams comes from added synthetic progesterone, not the wild yam itself
- The Combination of Diosgenin, Vitamin D, and α-Lactalbumin Normalizes the Menstrual Cycle in Women with PCOS of Phenotype D: A Pilot Clinical Study.
- Chemosensitization and Molecular Docking Assessment of Dio-NPs on Resistant Breast Cancer Cells to Tamoxifen.
- Herbal Treatment of Female Urogenital Atrophy: A Retrospective Cohort Analysis.
Memorial Sloan Kettering About Herbs · EMA Herbal Medicinal Product Monographs · American Botanical Council HerbMedPro